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New breath test to detect lung cancer

17 juillet 2007, 00:00

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Testing exhaled breath with a small sensor array can detect lung cancer with moderate accuracy, researchers report. The testing device, which contains 36 spots impregnated with chemically sensitive compounds, works by detecting patterns of volatile organic compounds in exhaled breath. These spots change colours when exposed to particular chemicals.

The goal was to determine if various colour patterns could be identified that accurately to detect lung cancer. The study included 49 patients with non-small-cell lung cancer, 73 with various other, non-malignant lung diseases, and 21 healthy ?controls.? Data from 70% of the subjects were used to identify a pattern that indicated the presence of lung cancer, which was then tested in the remaining 30%.The predictive pattern identified by the researchers was able to spot 73% of cancers, while it incorrectly identified 28% of nonmalignant conditions as cancerous. ?Further work may clarify the nature of the distinct breath constituents,? conclude Dr. Peter J. Mazzone, from The Cleveland Clinic, Ohio, and colleagues.

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